# 使用 Homebrew, apt 安装 vcfanno 查看 vcfanno 的安装路径、可执行文件、元数据以及面向 AI 代理工作流的安全说明。 ## 安装 ```sh sudo av install brew:vcfanno ``` 其他安装命令: ### macOS - Homebrew (100%): ```sh brew install vcfanno ``` 证据: local Homebrew formula metadata ### Linux - Debian apt (92%): ```sh sudo apt install vcfanno ``` 证据: Debian stable package indexes: vcfanno from https://deb.debian.org/debian/dists/stable/main/binary-amd64/Packages.xz ## 软件包事实 - **软件包键:** brew:vcfanno - **软件包管理器:** Homebrew - **软件包管理器页面:** - **版本:** 0.3.9 - **来源摘要:** Annotate a VCF with other VCFs/BEDs/tabixed files - **主页:** - **仓库:** - **上游文档:** - **许可证:** MIT - **源码归档:** - **最后更新:** 2026-06-16T21:19:58Z - **已生成:** 2026-07-08T18:08:21+00:00 ## 可执行文件 - vcfanno (cli) - vcfanno (别名) ## 构建依赖 - go ## 安装行为 - post-install 钩子: 未定义 - Bottle: 可用 于 arm64_linux, arm64_sequoia, arm64_sonoma, arm64_tahoe, sonoma, x86_64_linux ## 版本和新鲜度 - 页面生成时间: 2026-07-08 - 管理器版本: 0.3.9 - 管理器更新时间: 2026-06-16 - 本地数据: OK - 上游仓库: https://github.com/brentp/vcfanno - 检测到的最新版本: v0.3.9 (当前) ## 项目历史与用法 vcfanno is a Go command-line tool for annotating VCF records with fields from other VCF, BED, BAM, or tabix-indexed files. It became notable in genomics workflows because it treats annotation as a configurable stream-processing problem: many external resources can be summarized and added to the INFO field of a query VCF. ### 项目历史 The first GitHub release, v0.0.1, was published on April 29, 2015. Early 2015 releases quickly added support for annotating variant ends, BED files, custom scripting, and an API, which matches the project's focus on flexible annotation rather than a fixed database. Pedersen, Layer, and Quinlan published the vcfanno software paper in Genome Biology on June 1, 2016. The paper framed the problem as integrating genome annotations from diverse file formats and described vcfanno as extracting and summarizing attributes from multiple annotation files into the INFO column of the original VCF. ### 采用历史 The Genome Biology paper reported strong performance on whole-genome annotation workloads, including roughly 85,000 variants per second with 50 attributes from 17 commonly used annotation resources. That performance claim helped establish vcfanno as a practical tool for large human variant datasets as well as non-human species. The project README asks users to cite the paper and shows active maintenance through many GitHub releases, including v0.3.9 in June 2026. It is also packaged by Bioconda and distribution package managers, which places it in the standard bioinformatics command-line ecosystem. ### 使用方式 Users write a TOML configuration with one or more `[[annotation]]` blocks that name source files, fields or columns, operations, and output INFO names. vcfanno then streams a query VCF and writes an annotated VCF, commonly with `-p` for parallelism and optional Lua scripts for custom reductions. Common tasks include overlaying population allele frequencies, conservation scores, ClinVar or ExAC-like annotations, BED-derived regional scores, BAM-derived coverage summaries, and structural-variant endpoint annotations onto a study VCF before filtering or interpretation. ### 为什么软件包爱好者会关心 vcfanno matters to package people because it turns a pile of tabix-indexed genomics resources into a reproducible, reviewable config file and one CLI invocation. That is exactly the shape package managers like: a small binary that composes with bgzip/tabix, pipes, VCF validators, and downstream filters. It also represents the post-VCF-standard tooling wave: once VCF became the lingua franca, the hard day-to-day problem shifted to attaching the right outside evidence to millions of variants quickly and repeatably. ### 时间线 - 2015-04-29: vcfanno v0.0.1 is published as the initial GitHub release. - 2015-05-04: v0.0.2 adds support for annotating ends of variants such as CNVs and SVs. - 2016-06-01: The Genome Biology vcfanno paper is published. - 2026-06-16: GitHub lists v0.3.9 as the latest release. ### Related projects - VCFtools and HTSlib provide the broader VCF and indexed-file ecosystem that vcfanno workflows build on. - vcflib is a companion VCF-processing toolkit; the 2022 vcflib paper also points to vcfanno as a related tool for adding annotations from VCFs and BED files. - GATK, FreeBayes, ExAC-style resources, ClinVar-style resources, and tabix-indexed annotation files are common upstream or companion inputs in vcfanno pipelines. ### 来源 - - - - ## 安全说明 没有找到 vcfanno 的匹配本地密钥处理 manifest。Nucleus 软件包元数据仍在此发布，以便未来覆盖拥有稳定的软件包 URL。 ## 源数据库详情 - **Source Database:** Homebrew formula API - **Tap:** homebrew/core - **Full Name:** vcfanno - **Version Scheme:** 0 - **Revision:** 0 - **Bottle Stable Root URL:** - **Deprecated:** no - **Disabled:** no - **Keg Only:** no - **URL Keys:** stable ## 其他软件包管理器记录 - Debian apt - vcfanno - 0.3.5+ds-2+b9: normalized package name match | Debian stable package indexes: vcfanno from https://deb.debian.org/debian/dists/stable/main/binary-amd64/Packages.xz | annotate a VCF with other VCFs/BEDs/tabixed files | https://github.com/brentp/vcfanno - Debian apt - vcfanno-examples - 0.3.5+ds-2: normalized package name match | Debian stable package indexes: vcfanno-examples from https://deb.debian.org/debian/dists/stable/main/binary-amd64/Packages.xz | examples for vcfanno: annotate a VCF with other VCFs/BEDs/tabixed files | https://github.com/brentp/vcfanno - Ubuntu apt - vcfanno - 0.3.5+ds-2: normalized package name match | Ubuntu 24.04 LTS package indexes: vcfanno from https://archive.ubuntu.com/ubuntu/dists/noble/universe/binary-amd64/Packages.gz | annotate a VCF with other VCFs/BEDs/tabixed files | https://github.com/brentp/vcfanno - Ubuntu apt - vcfanno-examples - 0.3.5+ds-2: normalized package name match | Ubuntu 24.04 LTS package indexes: vcfanno-examples from https://archive.ubuntu.com/ubuntu/dists/noble/universe/binary-amd64/Packages.gz | examples for vcfanno: annotate a VCF with other VCFs/BEDs/tabixed files | https://github.com/brentp/vcfanno ## 相关链接 - [Terminal utility packages](https://www.automicvault.com/zh-hans/pkg/terminal-utilities/) - Matched terminal and command-line workflow metadata. - [Language runtime packages](https://www.automicvault.com/zh-hans/pkg/language-runtime-packages/) - Matched language runtime, compiler, or interpreter metadata. - [Networking and protocol packages](https://www.automicvault.com/zh-hans/pkg/networking-protocol-tools/) - Matched network, protocol, or remote-service metadata. - [Scientific computing packages](https://www.automicvault.com/zh-hans/pkg/scientific-computing-tools/) - Matched scientific computing metadata. - [go](https://www.automicvault.com/zh-hans/pkg/brew/go/) - Build dependency declared by Homebrew. - [vcflib](https://www.automicvault.com/zh-hans/pkg/brew/vcflib/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science, vcf. - [vcftools](https://www.automicvault.com/zh-hans/pkg/brew/vcftools/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science, vcf. - [abricate](https://www.automicvault.com/zh-hans/pkg/brew/abricate/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [gffread](https://www.automicvault.com/zh-hans/pkg/brew/gffread/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [minigraph](https://www.automicvault.com/zh-hans/pkg/brew/minigraph/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [stringtie](https://www.automicvault.com/zh-hans/pkg/brew/stringtie/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [tabixpp](https://www.automicvault.com/zh-hans/pkg/brew/tabixpp/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [echtvar](https://www.automicvault.com/zh-hans/pkg/brew/echtvar/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science, variant-annotation. ## Combined YAML source View the package source record on GitHub. [combined/vcfanno.yml](https://github.com/automic-vault/db/blob/main/combined/vcfanno.yml) ## 来源 - Nucleus package database - Geiger risk classifier - package-page enrichment - curated package history - package version freshness - av.db category and tag curation - package relationship graph - external package-manager database matches - cross-ecosystem install command graph