# 使用 Homebrew 安装 echtvar 查看 echtvar 的安装路径、可执行文件、元数据以及面向 AI 代理工作流的安全说明。 ## 安装 ```sh sudo av install brew:echtvar ``` 其他安装命令: ### macOS - Homebrew (100%): ```sh brew install echtvar ``` 证据: local Homebrew formula metadata ## 软件包事实 - **软件包键:** brew:echtvar - **软件包管理器:** Homebrew - **软件包管理器页面:** - **版本:** 0.2.4 - **来源摘要:** Rapid variant annotation and filtering - **主页:** - **仓库:** - **上游文档:** - **许可证:** MIT - **源码归档:** - **最后更新:** 2026-04-30T17:38:56Z - **已生成:** 2026-07-08T18:08:21+00:00 ## 可执行文件 - echtvar (cli) - echtvar (别名) ## 依赖 - openssl@3 ## 构建依赖 - cmake - pkgconf - rust ## macOS 提供的库 - bzip2 ## 安装行为 - post-install 钩子: 未定义 - Bottle: 可用 于 arm64_linux, arm64_sequoia, arm64_sonoma, arm64_tahoe, sonoma, x86_64_linux ## 版本和新鲜度 - 页面生成时间: 2026-07-08 - 管理器版本: 0.2.4 - 管理器更新时间: 2026-04-30 - 本地数据: OK - 上游仓库: https://github.com/brentp/echtvar - 检测到的最新版本: v0.2.4 (当前) ## 项目历史与用法 echtvar is a Rust command-line tool for rapid genomic variant annotation and filtering. Its package relevance is specialized but clear: it turns large population VCF resources into compact searchable archives that can annotate cohort VCF/BCF files quickly. ### 项目历史 The public repository was created in November 2021, and the first GitHub release, v0.1.0, was published in January 2022. The README describes echtvar as efficiently encoding variant allele frequency and other information from huge population datasets for rapid annotation at about one million variants per second. The project is backed by a Nucleic Acids Research article and is developed in the Jeroen de Ridder lab. Its README explains the core design: chunking the genome, encoding variants into compact integers when possible, using zip files, delta encoding, integer compression, and lookup tables for selected integer, float, or low-cardinality string fields. ### 采用历史 echtvar's adoption path is a scientific-tool path rather than a broad developer-tool path: users can download static binaries and pre-encoded gnomAD v3.1.2 resources from GitHub releases, or build the Rust project themselves. Homebrew packaging makes it easier to install the executable on developer and analysis workstations. The project is niche compared with general bioinformatics standards such as htslib, but it fills a practical need for fast annotation/filtering against large population datasets. ### 使用方式 A common workflow is to encode a population VCF once with echtvar encode, then reuse the resulting .echtvar.zip archive for many annotation runs with echtvar anno. The README shows annotation with multiple -e archive arguments and optional filtering expressions such as allele-frequency thresholds. Encode configuration uses JSON5 to select and rename VCF fields, while annotation consumes decomposed and normalized VCF/BCF inputs and can stream from stdin. ### 为什么软件包爱好者会关心 echtvar is interesting because it packages a paper-backed bioinformatics data structure as a small Rust CLI. Package managers help users get the executable, while GitHub releases carry large precomputed domain data that would not belong inside a formula. Its dependency story is also typical of modern bioinformatics packaging: htslib/rust-htslib for VCF/BCF I/O, compression libraries for speed, and a command-line interface meant to slot into pipelines. ### 时间线 - 2021: Public echtvar GitHub repository created. - 2022: v0.1.0 initial release published. - 2022: Nucleic Acids Research article page published for echtvar. - 2026: v0.2.4 released, with repository activity continuing. ### Related projects - The README credits htslib via rust-htslib for reading and writing BCF/VCF. - gnomAD is the main example population resource used for pre-encoded echtvar archives. - stream-vbyte, bincode, and fasteval are part of the implementation and expression-evaluation story described by the README. ### 来源 - - - - - ## 安全说明 narrow executable package without higher-risk signals. - **Geiger 风险:** 绿色 / 低 - narrow executable package without higher-risk signals ## 源数据库详情 - **Source Database:** Homebrew formula API - **Tap:** homebrew/core - **Full Name:** echtvar - **Version Scheme:** 0 - **Revision:** 0 - **Bottle Stable Root URL:** - **Deprecated:** no - **Disabled:** no - **Keg Only:** no - **URL Keys:** stable ## 相关链接 - [Terminal utility packages](https://www.automicvault.com/zh-hans/pkg/terminal-utilities/) - Matched terminal and command-line workflow metadata. - [Networking and protocol packages](https://www.automicvault.com/zh-hans/pkg/networking-protocol-tools/) - Matched network, protocol, or remote-service metadata. - [Scientific computing packages](https://www.automicvault.com/zh-hans/pkg/scientific-computing-tools/) - Matched scientific computing metadata. - [Homebrew utility packages](https://www.automicvault.com/zh-hans/pkg/brew-utility-packages/) - Matched Homebrew package provider. - [openssl@3](https://www.automicvault.com/zh-hans/pkg/brew/openssl-3/) - Runtime dependency declared by Homebrew. - [cmake](https://www.automicvault.com/zh-hans/pkg/brew/cmake/) - Build dependency declared by Homebrew. - [pkgconf](https://www.automicvault.com/zh-hans/pkg/brew/pkgconf/) - Build dependency declared by Homebrew. - [rust](https://www.automicvault.com/zh-hans/pkg/brew/rust/) - Build dependency declared by Homebrew. - [vcfanno](https://www.automicvault.com/zh-hans/pkg/brew/vcfanno/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science, variant-annotation. - [vcftools](https://www.automicvault.com/zh-hans/pkg/brew/vcftools/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science, variant-filtering. - [abricate](https://www.automicvault.com/zh-hans/pkg/brew/abricate/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [bbtools](https://www.automicvault.com/zh-hans/pkg/brew/bbtools/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [bioperl](https://www.automicvault.com/zh-hans/pkg/brew/bioperl/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [blast](https://www.automicvault.com/zh-hans/pkg/brew/blast/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [bowtie2](https://www.automicvault.com/zh-hans/pkg/brew/bowtie2/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [breseq](https://www.automicvault.com/zh-hans/pkg/brew/breseq/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [dxpy](https://www.automicvault.com/zh-hans/pkg/brew/dxpy/) - Local package facts share a topical domain. Shared terms: bioinformatics, cli, genomics, openssl, openssl-3. ## Combined YAML source View the package source record on GitHub. [combined/echtvar.yml](https://github.com/automic-vault/db/blob/main/combined/echtvar.yml) ## 来源 - Nucleus package database - Geiger risk classifier - package-page enrichment - curated package history - package version freshness - av.db category and tag curation - package relationship graph - cross-ecosystem install command graph