# Install sylph with Homebrew Ultrafast taxonomic profiling and genome querying for metagenomic samples. Version 0.9.0 via Homebrew; verified from local package data. ## Install ```sh sudo av install brew:sylph ``` Additional install commands: ### macOS - Homebrew (100%): ```sh brew install sylph ``` Evidence: local Homebrew formula metadata ## Package facts - **Package key:** brew:sylph - **Package manager:** Homebrew - **Package manager page:** - **Version:** 0.9.0 - **Source summary:** Ultrafast taxonomic profiling and genome querying for metagenomic samples - **Homepage:** - **Repository:** - **Upstream docs:** - **License:** MIT - **Source archive:** - **Generated:** 2026-07-08T07:18:31+00:00 ## Executables - sylph (cli) - sylph (alias) ## Build dependencies - cmake - rust ## Install behavior - Post-install hook: not defined - Bottle: available on arm64_linux, arm64_sequoia, arm64_sonoma, arm64_tahoe, sonoma, x86_64_linux ## Freshness - Page generated: 2026-07-08 - Package-manager version: 0.9.0 - Local data: ok - Upstream repository: https://github.com/bluenote-1577/sylph - Upstream latest detected: v0.9.0 (current) - info: No package-manager update timestamp was available. ## Project history and usage sylph is a Rust command-line tool for fast metagenomic profiling and containment average nucleotide identity querying from shotgun sequencing samples. It is packaged for scientists who want a small executable that can query or profile large genome databases quickly from the shell. ### Project history The official documentation describes sylph as a program for metagenomic profiling and containment ANI querying. Its core method uses k-mer containment with a statistical technique for low-coverage genomes, and the documentation cites the 2024 Nature Biotechnology paper by Jim Shaw and Yun William Yu. ### Adoption history The upstream README and documentation document installation through Bioconda, source builds with Rust/Cargo, and prebuilt x86-64 Linux binaries; the input package facts show Homebrew packaging as well. That mix reflects a bioinformatics CLI moving through both scientific package channels and general-purpose developer package managers. ### How it is used Common usage is to run sylph profile against a prebuilt or custom database, such as GTDB, with paired-end or single-end FASTQ files, or to run ANI querying to test whether a sample contains a genome related to a queried reference. The docs emphasize fast multi-sample profiling, custom databases, prebuilt databases, and support for short or long reads. ### Why package nerds care Package nerds care because sylph is a modern scientific CLI distributed as a Rust binary: it needs reproducible installation, large external databases, predictable CPU/RAM behavior, and channels such as Bioconda and Homebrew to reach different user communities. ### Timeline - 2024: Official documentation cites the sylph Nature Biotechnology paper by Jim Shaw and Yun William Yu. - Current README era: The GitHub README says all documentation moved to sylph-docs.github.io. - Homebrew packaging: The input package facts identify sylph as a Homebrew formula exposing the sylph executable. ### Related projects - Related tools and references named by the official docs include Kraken, MetaPhlAn, mOTUs, GTDB databases, Bioconda, Rust/Cargo, and sylph-tax. ### Sources - - - - source_facts.executables - source_facts.package-manager ## Security Notes narrow executable package without higher-risk signals. - **Geiger risk:** green / low - narrow executable package without higher-risk signals ## Source Database Details - **Source Database:** Homebrew formula API - **Tap:** homebrew/core - **Full Name:** sylph - **Version Scheme:** 0 - **Revision:** 0 - **Bottle Stable Root URL:** - **Deprecated:** no - **Disabled:** no - **Keg Only:** no - **URL Keys:** stable ## Related links - [Source-control packages](https://www.automicvault.com/pkg/source-control-tools/) - Belongs to a source-control command family. - [Terminal utility packages](https://www.automicvault.com/pkg/terminal-utilities/) - Matched terminal and command-line workflow metadata. - [Networking and protocol packages](https://www.automicvault.com/pkg/networking-protocol-tools/) - Matched network, protocol, or remote-service metadata. - [Scientific computing packages](https://www.automicvault.com/pkg/scientific-computing-tools/) - Matched scientific computing metadata. - [cmake](https://www.automicvault.com/pkg/brew/cmake/) - Build dependency declared by Homebrew. - [rust](https://www.automicvault.com/pkg/brew/rust/) - Build dependency declared by Homebrew. - [kraken2](https://www.automicvault.com/pkg/brew/kraken2/) - Shares av.db curated category or tags: bioinformatics, cli, metagenomics, science. - [mmseqs2](https://www.automicvault.com/pkg/brew/mmseqs2/) - Shares av.db curated category or tags: bioinformatics, cli, metagenomics, science. - [skani](https://www.automicvault.com/pkg/brew/skani/) - Shares av.db curated category or tags: bioinformatics, cli, metagenomics, science. - [spades](https://www.automicvault.com/pkg/brew/spades/) - Shares av.db curated category or tags: bioinformatics, cli, metagenomics, science. - [vsearch](https://www.automicvault.com/pkg/brew/vsearch/) - Shares av.db curated category or tags: bioinformatics, cli, metagenomics, science. - [abpoa](https://www.automicvault.com/pkg/brew/abpoa/) - Shares av.db curated category or tags: bioinformatics, cli, science. - [abricate](https://www.automicvault.com/pkg/brew/abricate/) - Shares av.db curated category or tags: bioinformatics, cli, science. - [abyss](https://www.automicvault.com/pkg/brew/abyss/) - Shares av.db curated category or tags: bioinformatics, cli, science. ## Combined YAML source View the package source record on GitHub. [combined/sylph.yml](https://github.com/automic-vault/db/blob/main/combined/sylph.yml) ## Sources - Nucleus package database - Geiger risk classifier - package-page enrichment - curated package history - package version freshness - av.db category and tag curation - package relationship graph - cross-ecosystem install command graph