# Install minigraph with Homebrew Proof-of-concept seq-to-graph mapper and graph generator. Version 0.21 via Homebrew; verified from local package data. ## Install ```sh sudo av install brew:minigraph ``` Additional install commands: ### macOS - Homebrew (100%): ```sh brew install minigraph ``` Evidence: local Homebrew formula metadata ## Package facts - **Package key:** brew:minigraph - **Package manager:** Homebrew - **Package manager page:** - **Version:** 0.21 - **Source summary:** Proof-of-concept seq-to-graph mapper and graph generator - **Homepage:** - **Repository:** - **Upstream docs:** - **License:** MIT - **Source archive:** - **Generated:** 2026-07-08T07:18:31+00:00 ## Executables - minigraph (cli) - minigraph (alias) ## Install behavior - Post-install hook: not defined - Bottle: available on arm64_linux, arm64_sequoia, arm64_sonoma, arm64_tahoe, sonoma, x86_64_linux ## Freshness - Page generated: 2026-07-08 - Package-manager version: 0.21 - Local data: ok - Upstream repository: https://github.com/lh3/minigraph - Upstream latest detected: v0.21 (current) - info: No package-manager update timestamp was available. ## Project history and usage minigraph is Heng Li's sequence-to-graph mapper and pangenome graph generator. The GitHub project describes it as a tool that aligns query sequences against a sequence graph and incrementally augments that graph with long divergent subsequences; the project documentation also notes that a significant portion of the source derives from minimap2, Li's pairwise nucleotide aligner. ### Project history The tool sits in the pangenome era of bioinformatics, where multiple high-quality assemblies are represented as a graph rather than flattened into one linear reference. The 2020 Genome Biology paper by Li, Feng, and Chu introduced the design and construction of reference pangenome graphs with minigraph, including a graph-based data model and formats intended to preserve coordinates against a linear reference. The command-line workflow maps sequences to sequences or graphs, emits PAF/GAF-style mappings, builds rGFA graphs from reference and sample assemblies, and can feed structural-variation extraction through gfatools. ### How it is used Its adoption history is tied to pangenome-reference research rather than general-purpose package use. Later Minigraph-Cactus work used minigraph to construct a structural-variation graph from input assemblies before Cactus refined it into richer pangenome graph outputs, and that pipeline demonstrated scaling to 90 human haplotypes from the Human Pangenome Reference Consortium. In package managers, minigraph is a specialist bioinformatics CLI for researchers building or testing genome graphs, often alongside minimap2, gfatools, vg, Cactus, and Bioconda-style scientific software stacks. ### Sources - - - - - - - ## Security Notes narrow executable package without higher-risk signals. - **Geiger risk:** green / low - narrow executable package without higher-risk signals ## Source Database Details - **Source Database:** Homebrew formula API - **Tap:** homebrew/core - **Full Name:** minigraph - **Version Scheme:** 0 - **Revision:** 0 - **Bottle Stable Root URL:** - **Deprecated:** no - **Disabled:** no - **Keg Only:** no - **URL Keys:** stable ## Related links - [Source-control packages](https://www.automicvault.com/pkg/source-control-tools/) - Belongs to a source-control command family. - [Terminal utility packages](https://www.automicvault.com/pkg/terminal-utilities/) - Matched terminal and command-line workflow metadata. - [Developer build packages](https://www.automicvault.com/pkg/developer-build-tools/) - Matched build, compiler, generator, or developer workflow metadata. - [Networking and protocol packages](https://www.automicvault.com/pkg/networking-protocol-tools/) - Matched network, protocol, or remote-service metadata. - [abricate](https://www.automicvault.com/pkg/brew/abricate/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [gffread](https://www.automicvault.com/pkg/brew/gffread/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [stringtie](https://www.automicvault.com/pkg/brew/stringtie/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [tabixpp](https://www.automicvault.com/pkg/brew/tabixpp/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [vcfanno](https://www.automicvault.com/pkg/brew/vcfanno/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [vcflib](https://www.automicvault.com/pkg/brew/vcflib/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [vcftools](https://www.automicvault.com/pkg/brew/vcftools/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [bbtools](https://www.automicvault.com/pkg/brew/bbtools/) - Shares av.db curated category or tags: bioinformatics, cli, genomics, science. - [miniprot](https://www.automicvault.com/pkg/brew/miniprot/) - Local package facts share a topical domain. Shared terms: bioinformatics, cli, genomics, mapping, science. - [minimap2](https://www.automicvault.com/pkg/brew/minimap2/) - Local package facts share a topical domain. Shared terms: bioinformatics, cli, genomics, science, sequence. ## Combined YAML source View the package source record on GitHub. [combined/minigraph.yml](https://github.com/automic-vault/db/blob/main/combined/minigraph.yml) ## Sources - Nucleus package database - Geiger risk classifier - package-page enrichment - curated package history - package version freshness - av.db category and tag curation - package relationship graph - cross-ecosystem install command graph